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A low level of thyroxine, which is the primary hormone produced by the thyroid gland, indicates that the body is not producing enough thyroid hormone, leading to a state known as hypothyroidism. In this condition, the metabolic processes in the body slow down, leading to symptoms such as fatigue, weight gain, sensitivity to cold, and depression.

Thyroxine, also known as T4, plays a crucial role in regulating metabolism, heart rate, temperature, and overall energy levels. When levels of thyroxine are low, it signifies that the thyroid gland is underactive, which is characteristic of hypothyroidism.

In contrast, hyperthyroidism is associated with high levels of thyroxine, as the thyroid gland is overactive. Diabetes Mellitus relates to insulin production and blood sugar regulation, while adrenal insufficiency pertains to insufficient production of hormones by the adrenal glands, not the thyroid. Therefore, a low thyroxine level specifically points towards hypothyroidism.